CXCL5/CXCR2 modulates inflammation-mediated neural repair after optic nerve injury
نویسندگان
چکیده
Previous studies reported that mild inflammation promotes retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve (ON) injury with involvement of infiltrating macrophages neutrophils. Here we aimed to evaluate the regulation main inflammatory chemokine pathway CXCL5/CXCR2 in inflammation-mediated RGC mice ON injury. The expressions cellular locations CXCL5 CXCR2 were confirmed mouse retina. Treatment effects recombinant antagonist SB225002 studied explant culture model or without lens number RGCs, regenerating axons, cells determined, activation Akt andSTAT3 signaling pathways evaluated. Cxcr2 Cxcl5 increased Addition promoted neurite outgrowth increase activated microglia, which was inhibited by clodronate liposomes. Recombinant also alleviated death injury, injury-induced protection CD68+ cells. infiltration activation, attenuated promotion effect on through reduction activation. further enhances induced is antagonist. could be a potential therapeutic target for
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2021
ISSN: ['1090-2430', '0014-4886']
DOI: https://doi.org/10.1016/j.expneurol.2021.113711